A simple method for preparation of N-mono- and N,N-di-alkylated a-amino acids
نویسندگان
چکیده
Reactions of a-amino acids with ketones under hydrogenation conditions using 20% Pd(OH)2/C as the catalyst gave N-mono-alkylated amino acids in high yields. Reductive methylation of N-mono-alkylated amino acids under the same hydrogenation conditions at 50°C afforded N,N-di-alkylated amino acids in excellent yields. This simple method has been used to synthesize N-monoand N,N-di-alkylated amino acids on a scale of 200 g. © 2000 Elsevier Science Ltd. All rights reserved.
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